DARPP-32抗體

【背景資料】：DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein) is a cytosolic protein highly enriched spiny neurons of the neostriatum. DARPP-32 is a bifunctional signal transduction molecule that controls serine/threonine kinase and serine/threonine phosphatase activity depending on the phosphrylation state of the protein. Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at threonine 34 converts it into an inhibitor of protein phosphatase 1. DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (cdk5). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological and behavioral phenotype.

【應(yīng)用類(lèi)型】：Western blotting (0.5-4 μg/ml). However, the optimal concentrations should be determined individually. Rat brain cortex tissue lysate can be used as a positive control. The antibody recognizes 32 kDa DARPP-32 of human, mouse, and rat origins.

【來(lái)源宿主】：兔

【反應(yīng)性】：經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠、大鼠種屬來(lái)源的DARPP-32蛋白發(fā)生免疫反應(yīng)。

【保存建議】：提供的DARPP-32抗體產(chǎn)品為100 μg 無(wú)色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS緩沖液中。請(qǐng)將該DARPP-32抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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