FAK抗體

【背景資料】：Focal adhesion kinase was identified as a 125 kDa substrate for the intrinsic protein tyrosine kinase activity of Src encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique as compared to other proteins described to date. Localization of p125 by immunofluorescence suggests that it is primarily found in cellular focal adhesions leading to its designation as focal adhesion kinase (FAK). FAK is concentrated at the basal edge of only those basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds and is activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the reepithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein coupled receptors.

【應用類型】：Western blotting (1-2 μg/ml), immunoprecipitation (5-20 μg/ml), and immunocytochemistry (10-20 μg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 125 kDa FAK of human, mouse, and rat origins.

【來源宿主】：兔

【反應性】：經(jīng)檢測驗證，可與人、小鼠、大鼠種屬來源的FAK蛋白發(fā)生免疫反應。

【保存建議】：提供的FAK抗體產(chǎn)品為100 μg 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS緩沖液中。請將該FAK抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。

BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的領導者。BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力。包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具。其產(chǎn)品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域。作為BioVision中國區(qū)域總代理，艾美捷與BioVision一道為研究者們提供最好、最新細胞生物學研究工具而不斷擴大產(chǎn)品及服務質(zhì)量。

更詳細產(chǎn)品說明及價格請點擊FAK抗體查詢或致電400-6800-868與BioVision中國區(qū)域授權總代理艾美捷科技有限公司垂詢。