PAK4抗體

【背景資料】：The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region. It has been demonstrated that phosphorylation of serine 474 of PAK4 may play a pivotal role in the activity and function of PAK4 kinase

【應(yīng)用類型】：Western blot analysis (0.5-4 μg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~60-70 kDa Pak4 in samples of human, mouse, and rat origins. The antibody does not cross-react with other Paks. Reactivity to other species has not been tested.

【來源宿主】：兔

【反應(yīng)性】：經(jīng)檢測驗(yàn)證，可與人、小鼠、大鼠、倉鼠種屬來源的PAK4蛋白發(fā)生免疫反應(yīng)。

【保存建議】：提供的PAK4抗體產(chǎn)品為100 μg 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)緩沖液中。請(qǐng)將該P(yáng)AK4抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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更詳細(xì)產(chǎn)品說明及價(jià)格請(qǐng)點(diǎn)擊PAK4抗體查詢或致電400-6800-868與BioVision中國區(qū)域授權(quán)總代理艾美捷科技有限公司垂詢。