Proteinase Inhibitor 9 (PI9)抗體

【背景資料】：Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.

【應用類型】：Western blotting (2-4 μg/ml) and Immunohistochemistry (20 μg/ml). It recognizes 42 kDa native human PI-9 and the 63 kDa PI-9 complexed to granzyme B. Reactivity to other species has not been tested.

小鼠

【反應性】：經(jīng)檢測驗證，可與人種屬來源的Proteinase Inhibitor 9 (PI9)蛋白 發(fā)生免疫反應。

【保存建議】：提供的Proteinase Inhibitor 9 (PI9)抗體 產(chǎn)品為100 μg 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS緩沖液中。請將該Proteinase Inhibitor 9 (PI9)抗體 產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。

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