皮膚癌腫瘤標志物檢測試劑盒

皮膚癌腫瘤標志物檢測試劑盒

Skin Neoplasms Molecular Marker (CSNK2A1,CSNK2B and ERBB4) Detection Kit
 
Description: The kit provides a means of performing Skin Neoplasms detection method based on kinase activity assays. Three targets of molecular marker (CSNK2A1, CSNK2B and ERBB4) are involved in Skin Neoplasms. This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of CSNK2A1, CSNK2B and ERBB4 which indicate the prognosis of Skin Neoplasms.


Molecular Markers in Skin Neoplasms

 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Skin Neoplasms	CSNK2A1	1457	marker/mechanism
Skin Neoplasms	CSNK2B	1460	marker/mechanism
Skin Neoplasms	ERBB4	2066	marker/mechanism

- Molecular markers for drug discovery and life science research (mechanism).

Peptide Core Sequence: 

Specific Substrate-Peptides for Skin Neoplasms Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Reaction Type
CSNK2A1	Peptides Mix	Ser-106	Phosphorylation
CSNK2B	Peptides Mix	Ser-942	Phosphorylation
ERBB4	Peptides Mix	Ser-780	Phosphorylation

Label of Substrate-Peptides:  Biotinylated

Quality Control: The substrate peptide was selected using our Skin Neoplasms Detection Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 
Store at 4 °C, Avoid Freeze.


Background:

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. Casein kinase II subunit beta is an protein that in humans is encoded by the CSNK2B gene. This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized. Mutations in this gene have been associated with cancer.
 
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