慢性髓系白血病標(biāo)志物檢測試劑盒

慢性髓系白血病（BCR-ABL陽性）標(biāo)志物檢測試劑盒

Leukemia(Myelogenous, Chronic, BCR-ABL Positive) Molecular Marker (MAPK14) Detection Kit

Description: The kit provides a means of performing Leukemia (Myelogenous, Chronic, BCR-ABL Positive) detection method based on kinase activity assays. Three targets of molecular marker (MAPK14) are involved in Leukemia (Myelogenous, Chronic, BCR-ABL Positive). This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of MAPK14 which indicate the prognosis of Leukemia (Myelogenous, Chronic, BCR-ABL Positive). 


Molecular Markers in Leukemia (Myelogenous, Chronic, BCR-ABL Positive)

 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic

- Molecular markers for drug discovery and life science research (therapeutic).

Peptide Core Sequence: 

Specific Substrate-Peptides for Leukemia (Myelogenous, Chronic, BCR-ABL Positive) Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Reaction Type
MAPK14	Peptides Mix	Ser-543	Phosphorylation
MAPK14	Peptides Mix	Ser-387	Phosphorylation
MAPK14	Peptides Mix	Ser-726	Phosphorylation

Label of Substrate-Peptides:  Biotinylated

Quality Control: The substrate peptide was selected using our Leukemia (Myelogenous, Chronic, BCR-ABL Positive) Detection Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 
Store at 4 °C, Avoid Freeze.


Background:

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
 
 
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