前列腺癌腫瘤分子標(biāo)志物檢測(cè)試劑盒

前列腺癌腫瘤分子標(biāo)志物檢測(cè)試劑盒
 

貨號(hào): BR-1102P       規(guī)格: 96 Assay      價(jià)格: ￥3735.00

Prostate Cancer Molecular Marker (CHEK2) Detection Kit
 
Description: The kit provides a means of performing Prostate Cancer detection method based on kinase activity assays. Three targets of molecular marker (EPHB2 and ERBB2) are involved in Prostate Cancer. This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of EPHB2 and ERBB2 which indicate the prognosis of Prostate Cancer.


Molecular Markers in Prostate Cancer

 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Prostate Cancer	EPHB2	2048	marker/mechanism
Prostate Cancer	ERBB2	2064	marker/mechanism

- Molecular markers for drug discovery and life science research (mechanism or therapeutic).


Peptide Core Sequence: 

Specific Substrate-Peptides for Prostate Cancer Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Reaction Type
EPHB2	Peptides Mix	Tyr-66	Phosphorylation
ERBB2	Peptides Mix	Tyr-1023	Phosphorylation

Label of Substrate-Peptides:  Biotinylated

Quality Control: The substrate peptide was selected using our Prostate Cancer Detection Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 
Store at 4 °C, Avoid Freeze.


Background:

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. EphB2 is part of the NMDA signaling pathway. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. It is encoded within the genome by HER2/neu, a known proto-oncogene. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. However, ErbB receptors dimerise on ligand binding, and HER2 is the preferential dimerisation partner of other members of the ErbB family.The HER2 gene is a proto-oncogene located at the long arm of human chromosome 17(17q21-q22). Approximately 30% of breast cancers have an amplification of the HER2/neu gene or overexpression of its protein product. In clinical usage, HER2/neu is important as the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where the HER2/neu receptor is overexpressed. One of the mechanisms of how trastuzumab works after it binds to HER2 is by increasing p27, a protein that halts cell proliferation.
 
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