Phospho-Stat3抗體

【背景資料】：Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

【應(yīng)用類型】：Western blotting (1-4 μg/ml), immunoprecipitation (20 mg/ml), and Immunohistochemistry (20 μg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~86 kDa phosphorylated Stat3 (Ser727) of human and mouse origins. Reactivity to other species has not been tested.

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【反應(yīng)性】：經(jīng)檢測驗證，可與人、小鼠種屬來源的Phospho-Stat3蛋白 發(fā)生免疫反應(yīng)。

【保存建議】：提供的Phospho-Stat3抗體 產(chǎn)品為100 μg 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS緩沖液中。請將該Phospho-Stat3抗體 產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。

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