Phospho-c-Myc抗體

【背景資料】：The transcription factor c-Myc is a short-lived nuclear phosphoprotein involved in cell proliferation, differentiation and cancer regulation. c-Myc binds to DNA and activates transcription as a heterodimeric complex with Max. c-Myc is phosphorylated in vitro by MAP Kinase at Ser62 and in vivo c-Myc is phosphorylated at both Thr58 and Ser62. Mutation of The58 and Ser62 to Ala inhibits the ability of c-Myc to activate transcription, suggesting that phosphorylation regulates the ability of c-Myc to stimulate transcription. c-Myc appears to regulate multiple aspects of growth control: it promotes cell proliferation in the presence of cdk inhibitors and induces apoptosis with overexpression in serum deprived cells.

【應(yīng)用類型】：Western blot analysis (0.5-4 μg/ml), immunoprecipitation (2-4 μg/ml), and Immunohistochemistry (10-20 μg/ml). However, the optimal conditions should be determined individually. The Phospho-c-Myc (Thr58/Ser62) antibody detects only phosphorylated Thr58/Ser62 of c-Myc. It does not react with non-phosphorylated c-Myc.

兔

【反應(yīng)性】：經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠、大鼠種屬來源的Phospho-c-Myc蛋白 發(fā)生免疫反應(yīng)。

【保存建議】：提供的Phospho-c-Myc抗體 產(chǎn)品為100 μg 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油, 1% BSA, 0.02%硫柳汞的PBS (pH 7.2)緩沖液中。請(qǐng)將該P(yáng)hospho-c-Myc抗體 產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者。BioVision在開發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力。包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具。其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域。作為BioVision中國(guó)區(qū)域總代理，艾美捷與BioVision一道為研究者們提供最好、最新細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量。

更詳細(xì)產(chǎn)品說明及價(jià)格請(qǐng)點(diǎn)擊Phospho-c-Myc抗體 查詢或致電400-6800-868與BioVision中國(guó)區(qū)域授權(quán)總代理艾美捷科技有限公司垂詢。