Phospho-Mek1/2抗體

【背景資料】：MAP kinase kinase 1 (Mek1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.

【應(yīng)用類型】：Western blotting (1:200-1000) and immunocytochemistry (1:100-200). However, the optimal concentrations should be determined individually. The antibody recognizes 45 kDa phospho-Mek1/2 (Ser217/221). It does not detect the unphosphorylated protein.

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【反應(yīng)性】：經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠、大鼠種屬來源的Phospho-Mek1/2蛋白 發(fā)生免疫反應(yīng)。

【保存建議】：提供的Phospho-Mek1/2抗體 產(chǎn)品為100 μl 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02% 疊氮鈉的PBS緩沖液中。請(qǐng)將該P(yáng)hospho-Mek1/2抗體 產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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