【背景資料】：The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.
【應用類型】：Western blotting (1-4 μg/ml). However, the optimal concentrations should be determined individually.The antibody recognizes a ~50 kDa band from samples of human origin. Reactivity to other species has not been tested. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control.
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【反應性】：經檢測驗證，可與人、小鼠種屬來源的MMP-12蛋白 發(fā)生免疫反應。
【保存建議】：提供的MMP-12抗體 產品為100 μg 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS緩沖液中。請將該MMP-12抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。
BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的領導者。BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力。包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創(chuàng)新的研究工具。其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域。作為BioVision中國區(qū)域總代理，艾美捷與BioVision一道為研究者們提供最好、最新細胞生物學研究工具而不斷擴大產品及服務質量。
更詳細產品說明及價格請點擊MMP-12抗體 查詢或致電400-6800-868與BioVision中國區(qū)域授權總代理艾美捷科技有限公司垂詢。
