TLR7抗體

【背景資料】：The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. TLR6 and TLR7 induce NFkB signaling upon activation, suggesting they play a role in immune reponse. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.

【應(yīng)用類型】：Western blotting (1:500-1000 dilution). However, the optimal conditions should be determined individually. Ramos cell lysate can be used as a positive control.

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【反應(yīng)性】：經(jīng)檢測(cè)驗(yàn)證，可與人種屬來(lái)源的TLR7蛋白 發(fā)生免疫反應(yīng)。

【保存建議】：提供的TLR7抗體 產(chǎn)品為100 μl 無(wú)色溶液，其濃度為N/A，溶解于包含有30%甘油, 0.5% BSA, 0.02%硫柳汞的PBS (pH 7.2)緩沖液中。請(qǐng)將該TLR7抗體 產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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