重組小鼠LAG3(淋巴細(xì)胞活化基因3蛋白)

特別提示：包括重組小鼠LAG3(淋巴細(xì)胞活化基因3蛋白)在內(nèi)，本公司的所有產(chǎn)品僅可用于科研實(shí)驗(yàn)，嚴(yán)禁用于臨床醫(yī)療及其他非科研用途！

產(chǎn)品名稱：重組小鼠LAG3(淋巴細(xì)胞活化基因3蛋白)
英文名稱：Recombinant Mouse Lymphocyte Activation Gene 3 Protein
產(chǎn)品貨號(hào)：JN1421
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)制備而成，目的基因編碼的Ser23-Leu442在C端含有His標(biāo)簽。

LAG3 質(zhì)量控制：＞95%(還原性SDS-PAGE)

LAG3 制劑：凍干品

LAG3 保存：
凍干蛋白置于-20℃以下可長(zhǎng)期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個(gè)月。

LAG3 復(fù)溶：
打開(kāi)試劑管前請(qǐng)先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請(qǐng)溶于ddH2O。
復(fù)溶后，請(qǐng)根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于LAG3 ：
Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.

根據(jù)您的關(guān)注的重組小鼠LAG3(淋巴細(xì)胞活化基因3蛋白)，重組LAG3，rLAG3，重組小鼠LAG3，重組小鼠Lymphocyte Activation Gene 3 Protein，重組淋巴細(xì)胞活化基因3蛋白，重組Lymphocyte Activation Gene 3 Protein，重組小鼠淋巴細(xì)胞活化基因3蛋白，Recombinant Mouse Lymphocyte Activation Gene 3 Protein，rmLAG3，您可能還對(duì)以下產(chǎn)品有需求：
 

貨號(hào)	名稱	規(guī)格
JN0427	重組人干擾素α1(IFN-α1)	10μg|50μg|500μg|1mg
JN1966	重組人泛素結(jié)合酶E2-T(UBCE2T)	10μg|50μg|500μg|1mg
JN0628	重組人活化素ⅡA受體(活化素受體Ⅱa)	10μg|50μg|500μg|1mg
JN1644	重組人M-CSFR(CSF1R)(CD115)	10μg|50μg|500μg|1mg
JN1732	重組人Carboxypeptidase A1(羧肽酶A1)(CPA1)	10μg|50μg|500μg|1mg
JN1769	重組小鼠Cystatin F(胱抑素F)	10μg|50μg|500μg|1mg

關(guān)注重組小鼠LAG3(淋巴細(xì)胞活化基因3蛋白)，重組LAG3，rLAG3，重組小鼠LAG3，重組小鼠Lymphocyte Activation Gene 3 Protein，重組淋巴細(xì)胞活化基因3蛋白，重組Lymphocyte Activation Gene 3 Protein，重組小鼠淋巴細(xì)胞活化基因3蛋白，Recombinant Mouse Lymphocyte Activation Gene 3 Protein，rmLAG3的同時(shí)，為您推薦更多您可能感興趣的產(chǎn)品：



名稱：重組小鼠白介素IL-4(白細(xì)胞介素4)
貨號(hào)：JN0416
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達(dá)系統(tǒng)制備，目的基因編碼的His23-Ser140表達(dá)純化而來(lái)。

IL-4質(zhì)量控制：＞95%(還原性SDS-PAGE)。

IL-4制劑：凍干品

IL-4保存：
凍干蛋白可在-20℃長(zhǎng)期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個(gè)月，應(yīng)避免反復(fù)凍融。

IL-4復(fù)溶：
1、試劑開(kāi)蓋前請(qǐng)先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于IL-4：
Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α­helix structure. IL­4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL­4 is primarily expressed by Th2­biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.