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產(chǎn)品名稱:重組小鼠CTLA-4(CD152)
英文名稱:Recombinant Mouse Cytotoxic T-lymphocyte protein 4
產(chǎn)品貨號:JN1624
產(chǎn)品規(guī)格:10μg|50μg|500μg|1mg
本品由我們的哺乳動物細胞表達系統(tǒng)制備而成,目的基因編碼的Ala37-Asp161在C端帶有Fc標簽。
CTLA-4/CD152質量控制:>95%(還原性SDS-PAGE)
CTLA-4/CD152制劑:凍干品
CTLA-4/CD152保存:
凍干蛋白置于-20℃以下可長期保存,室溫條件下可穩(wěn)定保存3周。
復溶蛋白溶液可在4~7℃保存2~7天,可分裝后置于-20℃保存三個月。
CTLA-4/CD152復溶:
打開試劑管前請先離心。
復溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復溶后,請根據(jù)用量分裝凍存,避免反復凍融。
關于CTLA-4/CD152:
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
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