NFkB p65抗體

【背景資料】：NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

【應用類型】：Western blot analysis (1-4 μg/ml). However, the optimal conditions should be determined individually. A431 cells can be used as a positive control.

【來源宿主】：小鼠

【反應性】：經(jīng)檢測驗證，可與人、小鼠、大鼠種屬來源的NFkB p65蛋白發(fā)生免疫反應。

【保存建議】：提供的NFkB p65抗體產(chǎn)品為100 μg 無色溶液，其濃度為0.2 mg/ml，溶解于包含有1 mg/ml BSA和1.5 mM 疊氮鈉和50%甘油.的PBS緩沖液中。請將該NFkB p65抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。

BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的領導者。BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力。包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具。其產(chǎn)品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域。作為BioVision中國區(qū)域總代理，艾美捷與BioVision一道為研究者們提供最好、最新細胞生物學研究工具而不斷擴大產(chǎn)品及服務質量。

更詳細產(chǎn)品說明及價格請點擊NFkB p65抗體查詢或致電400-6800-868與BioVision中國區(qū)域授權總代理艾美捷科技有限公司垂詢。