【背景資料】：Mcl-1 (Myeloid cell leukemia-1) is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-β1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.
【應用類型】：Western blot analysis (0.5-4 μg/ml), immunoprecipitation (10-20 μg/ml), and Immunohistochemistry (10-20 μg/ml). However, the optimal conditions should be determined individually.
【來源宿主】：兔
【反應性】：經檢測驗證，可與人、小鼠、大鼠、猴種屬來源的Mcl-1蛋白發(fā)生免疫反應。
【保存建議】：提供的Mcl-1抗體產品為100 μg 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油, 0.5% BSA和0.01%硫柳汞的PBS (pH 7.2)緩沖液中。請將該Mcl-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融。
BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的領導者。BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力。包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創(chuàng)新的研究工具。其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域。作為BioVision中國區(qū)域總代理，艾美捷與BioVision一道為研究者們提供最好、最新細胞生物學研究工具而不斷擴大產品及服務質量。
更詳細產品說明及價格請點擊Mcl-1抗體查詢或致電400-6800-868與BioVision中國區(qū)域授權總代理艾美捷科技有限公司垂詢。
