NFkB p65抗體

【背景資料】：NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50 has an isoform called p49/p52, and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines (IL-1 & TNF, etc.), and viral infection, IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

【應(yīng)用類型】：Western blotting (0.5-4 μg/ml), immunocytochemistry (10-20μg/ml). However, the optimal conditions should be determined individually. The antibody detects primarily NFkB p65 in samples of human, mouse, and rat origins.

【來源宿主】：兔

【反應(yīng)性】：經(jīng)檢測驗證，可與人、小鼠、大鼠種屬來源的NFkB p65蛋白發(fā)生免疫反應(yīng)。

【保存建議】：提供的NFkB p65抗體產(chǎn)品為100 μg 無色溶液，其濃度為0.2 mg/ml，溶解于包含有25%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)緩沖液中。請將該NFkB p65抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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更詳細(xì)產(chǎn)品說明及價格請點擊NFkB p65抗體查詢或致電400-6800-868與BioVision中國區(qū)域授權(quán)總代理艾美捷科技有限公司垂詢。