Calcineurin A抗體

【背景資料】：Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.

【應(yīng)用類(lèi)型】：Western Blotting (1-4 μg/ml) and for immunoprecipitation (10-20 μg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects a 61 kDa band, corresponding to the expected molecular weight of Calcineurin A on immunoblots. A 32 kDa band can also be detected in human samples, presumably to be the cleavage product of Calcineurin A..

【來(lái)源宿主】：兔

【反應(yīng)性】：經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠、大鼠、倉(cāng)鼠、兔、牛種屬來(lái)源的Calcineurin A蛋白發(fā)生免疫反應(yīng)。

【保存建議】：提供的Calcineurin A抗體產(chǎn)品為100 μg 無(wú)色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)緩沖液中。請(qǐng)將該Calcineurin A抗體產(chǎn)品置于-20 ℃冷凍保存，建議分裝使用以避免反復(fù)凍融。

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更詳細(xì)產(chǎn)品說(shuō)明及價(jià)格請(qǐng)點(diǎn)擊Calcineurin A抗體查詢(xún)或致電400-6800-868與BioVision中國(guó)區(qū)域授權(quán)總代理艾美捷科技有限公司垂詢(xún)。