PEG10

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Species Cross-reactivity  H,M,Ra,P
 

Key Application  ELISA,WB，IP
 

Host  Mouse
 

Antibody type  Monoclonal antibody
 

Purified method  Affinity purified
 

Isotype  IgG1
 

Molecular Weight  55kDa
 

Sensitivity  This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins.
 

Immunogen  Purified recombinant human PEG10 protein fragments expressed in E.coli.
 

UniProt Number  Q86TG7
 

GeneBank ID  NM_001040152
 

Subcellular location  Nucleus. Cytoplasm
 

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
 

Altername  carcinoma differentiation-regulated protein,Mammalian ,retrotransposon-derived protein 2,Myelin expression factor 3-like protein 1,Short name=MEF3-like protein 1,Paternally expressed gene 10 protein,Retrotransposon gag domain-containing protein 3,Retrotransposon-derived gag-like polyprotein,Ty3/Gypsy-like protein
 

Gene_symbol  EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3
 

UniPort summary Function  Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5´-GCCTGTCTTT-3´ DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter
 

Entrez summary  This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]
 

Application Images :  
 

Western blot detection of PEG10 in Hela cell lysates using PEG10 antibody (1:1000 diluted). Predicted band size:55KDa. Observed band size:55KDa，95KDa

Immunoprecipitation analysis of Hela cell lysates using PEG10 antibody